Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.
Identifieur interne : 002972 ( Main/Exploration ); précédent : 002971; suivant : 002973Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.
Auteurs : Amélie Sabine [Suisse] ; Tatiana V. PetrovaSource :
- Advances in anatomy, embryology, and cell biology [ 0301-5556 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Calcineurine (métabolisme), Connexines (métabolisme), Facteurs de transcription Forkhead (métabolisme), Humains, Lymphangiogenèse, Mécanotransduction cellulaire, Régulation de l'expression des gènes au cours du développement, Signalisation du calcium, Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (physiologie).
- MESH :
- embryologie : Vaisseaux lymphatiques.
- métabolisme : Calcineurine, Connexines, Facteurs de transcription Forkhead.
- physiologie : Vaisseaux lymphatiques.
- Animaux, Humains, Lymphangiogenèse, Mécanotransduction cellulaire, Régulation de l'expression des gènes au cours du développement, Signalisation du calcium.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Calcineurin, Connexins, Forkhead Transcription Factors.
- embryology : Lymphatic Vessels.
- physiology : Lymphatic Vessels.
- Animals, Calcium Signaling, Gene Expression Regulation, Developmental, Humans, Lymphangiogenesis, Mechanotransduction, Cellular.
Abstract
The directional flow of lymph is maintained by hundreds of intraluminal lymphatic valves. Lymphatic valves are crucial to prevent lymphedema, accumulation of fluid in the tissues, and to ensure immune surveillance; yet, the mechanisms of valve formation are only beginning to be elucidated. In this chapter, we will discuss the main steps of lymphatic valve morphogenesis, the important role of mechanotransduction in this process, and the genetic program regulated by the transcription factor Foxc2, which is indispensable for all steps of valve development. Failure to form mature collecting lymphatic vessels and valves causes the majority of postsurgical lymphedema, e.g., in breast cancer patients. Therefore, this knowledge will be useful for diagnostics and development of better treatments of secondary lymphedema.
DOI: 10.1007/978-3-7091-1646-3_6
PubMed: 24276887
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001813
- to stream PubMed, to step Curation: 001813
- to stream PubMed, to step Checkpoint: 001813
- to stream Ncbi, to step Merge: 005F92
- to stream Ncbi, to step Curation: 005F92
- to stream Ncbi, to step Checkpoint: 005F92
- to stream Main, to step Merge: 002976
- to stream Main, to step Curation: 002972
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.</title><author><name sortKey="Sabine, Amelie" sort="Sabine, Amelie" uniqKey="Sabine A" first="Amélie" last="Sabine">Amélie Sabine</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, CHUV-UNIL, Ch. des Boveresses 155, CH-1066, Epalinges, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology, CHUV-UNIL, Ch. des Boveresses 155, CH-1066, Epalinges</wicri:regionArea><wicri:noRegion>Epalinges</wicri:noRegion></affiliation></author><author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V" last="Petrova">Tatiana V. Petrova</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24276887</idno><idno type="pmid">24276887</idno><idno type="doi">10.1007/978-3-7091-1646-3_6</idno><idno type="wicri:Area/PubMed/Corpus">001813</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001813</idno><idno type="wicri:Area/PubMed/Curation">001813</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001813</idno><idno type="wicri:Area/PubMed/Checkpoint">001813</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001813</idno><idno type="wicri:Area/Ncbi/Merge">005F92</idno><idno type="wicri:Area/Ncbi/Curation">005F92</idno><idno type="wicri:Area/Ncbi/Checkpoint">005F92</idno><idno type="wicri:doubleKey">0301-5556:2014:Sabine A:interplay:of:mechanotransduction</idno><idno type="wicri:Area/Main/Merge">002976</idno><idno type="wicri:Area/Main/Curation">002972</idno><idno type="wicri:Area/Main/Exploration">002972</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.</title><author><name sortKey="Sabine, Amelie" sort="Sabine, Amelie" uniqKey="Sabine A" first="Amélie" last="Sabine">Amélie Sabine</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, CHUV-UNIL, Ch. des Boveresses 155, CH-1066, Epalinges, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology, CHUV-UNIL, Ch. des Boveresses 155, CH-1066, Epalinges</wicri:regionArea><wicri:noRegion>Epalinges</wicri:noRegion></affiliation></author><author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V" last="Petrova">Tatiana V. Petrova</name></author></analytic><series><title level="j">Advances in anatomy, embryology, and cell biology</title><idno type="ISSN">0301-5556</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Calcineurin (metabolism)</term><term>Calcium Signaling</term><term>Connexins (metabolism)</term><term>Forkhead Transcription Factors (metabolism)</term><term>Gene Expression Regulation, Developmental</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (physiology)</term><term>Mechanotransduction, Cellular</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Calcineurine (métabolisme)</term><term>Connexines (métabolisme)</term><term>Facteurs de transcription Forkhead (métabolisme)</term><term>Humains</term><term>Lymphangiogenèse</term><term>Mécanotransduction cellulaire</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Signalisation du calcium</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcineurin</term><term>Connexins</term><term>Forkhead Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcineurine</term><term>Connexines</term><term>Facteurs de transcription Forkhead</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Calcium Signaling</term><term>Gene Expression Regulation, Developmental</term><term>Humans</term><term>Lymphangiogenesis</term><term>Mechanotransduction, Cellular</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Lymphangiogenèse</term><term>Mécanotransduction cellulaire</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Signalisation du calcium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The directional flow of lymph is maintained by hundreds of intraluminal lymphatic valves. Lymphatic valves are crucial to prevent lymphedema, accumulation of fluid in the tissues, and to ensure immune surveillance; yet, the mechanisms of valve formation are only beginning to be elucidated. In this chapter, we will discuss the main steps of lymphatic valve morphogenesis, the important role of mechanotransduction in this process, and the genetic program regulated by the transcription factor Foxc2, which is indispensable for all steps of valve development. Failure to form mature collecting lymphatic vessels and valves causes the majority of postsurgical lymphedema, e.g., in breast cancer patients. Therefore, this knowledge will be useful for diagnostics and development of better treatments of secondary lymphedema.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V" last="Petrova">Tatiana V. Petrova</name></noCountry><country name="Suisse"><noRegion><name sortKey="Sabine, Amelie" sort="Sabine, Amelie" uniqKey="Sabine A" first="Amélie" last="Sabine">Amélie Sabine</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002972 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002972 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24276887
|texte= Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24276887" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |